Endocrine Abstracts

Introduction: Somatostatin (SST) is a widely distributed polypeptide that modulates the endocrine and exocrine secretion, cellular proliferation and differentiation, and apoptosis via G protein-linked receptors. Our previous studies showed high SSTR expression in adrenocortical carcinoma (ACC), aldosterone producing adenoma (APA) and in cortisol producing adenoma (CPA). Only very few information are available about the effectiveness of SST analogs in adrenal tumors.<p clas...

In the diagnosis of Cushing’s disease (CD) desmopressin (dDAVP) stimulation test may be a convenient and more readily available alternative to CRH test; however the sensibility and specificity of ACTH response to dDAVP test has been reported in adult patients inferior to CRH test. In childhood patients with CD there are no data for the use of dDAVP test in this clinical setting. We studied 9 patients ranging in age from 11 to 19 years (7 females and 2 males) with a suspec...

Background: Familial isolated pituitary adenomas (FIPA) is a rare inherited disorder accounting for about 2% of pituitary adenomas. Mutations in the Aryl hydrocarbon receptor Interacting Protein (AIP) gene have been described in about 15% of FIPA families and rarely in early onset sporadic pituitary adenomas. Among the AIP mutations reported so far, the R304X represents, after the Finnish founder mutation Q14X, the second most common one.Me...